TMPRSS2, a novel membrane-anchored mediator in cancer pain
نویسندگان
چکیده
منابع مشابه
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing to its highly localized expression in the prostate and its overexpression in neoplastic prostate epithelium. Once activated, the serine protease domain of TMPRSS2 is released from the cell surface into the extracellular space. PAR (protease-activated receptor)-2 belongs to a family of G-protein-coupled recep...
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ژورنال
عنوان ژورنال: Pain
سال: 2015
ISSN: 0304-3959
DOI: 10.1097/j.pain.0000000000000130